Engineering a Bi-conical microchip as vascular stenosis model

Yan Li*, Jianchun Wang, Wei Wan, Chengmin Chen, Xueying Wang, Pei Zhao, Yanjin Hou, Hanmei Tian, Jianmei Wang, Krishnaswamy Nandakumar, Liqiu Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Vascular stenosis is always associated with hemodynamic changes, especially shear stress alterations. Herein, bi-conical shaped microvessels were developed through flexibly and precisely controlled templated methods for hydrogel blood-vessel-like microchip. The blood-vessel-like microvessels demonstrated tunable dimensions, perfusable ability, and good cytocompatibility. The microchips showed blood-vessel-like lumens through fine embeddedness of human umbilical vein endothelial cells (HUVECs) on the interior surface of hydrogel microchannels, which closely reproduced the morphology and functions of human blood vessels. In the gradual narrowing region of bi-conical shape, fluid flow generated wall shear stress, which caused cell morphology variations. Wall shear rates at the gradual narrowing region were simulated by FLUENT software. The results showed that our microchannels qualified for performance as a vascular stenosis-like model in evaluating blood hydrodynamics. In general, our blood-vessel-on-a-chip could offer potential applications in the prevention, diagnosis, and therapy of arterial thrombosis.

Original languageEnglish
Article number790
JournalMicromachines
Volume10
Issue number11
DOIs
StatePublished - 1 Nov 2019
Externally publishedYes

Keywords

  • Bi-conical
  • Blood-vessel-like
  • Microchip
  • Vascular stenosis
  • Wall shear rate

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