Efficiency of recrystallization methods for the purification of β-cyclodextrin

Wende Li; Harold Corke; Litian Zhang

doi:10.1002/star.19960481008

Efficiency of recrystallization methods for the purification of β-cyclodextrin

Wende Li^*, Harold Corke, Litian Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Cyclodextrins are an important class of products made from starch, and have many applications in the food and other industries. Among the cyclodextrins, β-cyclodextrin (β-CD) is the most important and is produced in the largest amount. Some commercial preparations of β-CD contain contaminants which must be eliminated to enhance the purity of the product. The purity of β-CD was increased by four different methods, i.e. recrystallization in water, and purification with isopropanol, cyclohexane, or isopropanol and cyclohexane. Purity of β-CD following the isopropanol method was over 99%, but the yield was only 40%. After cyclohexane treatment or the combined treatment with isopropanol and cyclohexane, purity was also over 99%, but yield was over 60%. Contaminants in commercial β-CD may be soluble or insoluble. Some contaminants would be bound in the inclusion cavity, and elimination of such contaminants by recrystallization in water was not successful. The purity and endothermic energy changes of β-CD were also determined by differential scanning calorimetry.

Original language	English
Pages (from-to)	382-385
Number of pages	4
Journal	Starch/Staerke
Volume	48
Issue number	10
DOIs	https://doi.org/10.1002/star.19960481008
State	Published - Oct 1996
Externally published	Yes

Access to Document

10.1002/star.19960481008

Cite this

@article{c646f0f3eaa34f4babb09c5629d2c81f,

title = "Efficiency of recrystallization methods for the purification of β-cyclodextrin",

abstract = "Cyclodextrins are an important class of products made from starch, and have many applications in the food and other industries. Among the cyclodextrins, β-cyclodextrin (β-CD) is the most important and is produced in the largest amount. Some commercial preparations of β-CD contain contaminants which must be eliminated to enhance the purity of the product. The purity of β-CD was increased by four different methods, i.e. recrystallization in water, and purification with isopropanol, cyclohexane, or isopropanol and cyclohexane. Purity of β-CD following the isopropanol method was over 99%, but the yield was only 40%. After cyclohexane treatment or the combined treatment with isopropanol and cyclohexane, purity was also over 99%, but yield was over 60%. Contaminants in commercial β-CD may be soluble or insoluble. Some contaminants would be bound in the inclusion cavity, and elimination of such contaminants by recrystallization in water was not successful. The purity and endothermic energy changes of β-CD were also determined by differential scanning calorimetry.",

author = "Wende Li and Harold Corke and Litian Zhang",

year = "1996",

month = oct,

doi = "10.1002/star.19960481008",

language = "英语",

volume = "48",

pages = "382--385",

journal = "Starch/Staerke",

issn = "0038-9056",

publisher = "Wiley-VCH Verlag",

number = "10",

}

TY - JOUR

T1 - Efficiency of recrystallization methods for the purification of β-cyclodextrin

AU - Li, Wende

AU - Corke, Harold

AU - Zhang, Litian

PY - 1996/10

Y1 - 1996/10

N2 - Cyclodextrins are an important class of products made from starch, and have many applications in the food and other industries. Among the cyclodextrins, β-cyclodextrin (β-CD) is the most important and is produced in the largest amount. Some commercial preparations of β-CD contain contaminants which must be eliminated to enhance the purity of the product. The purity of β-CD was increased by four different methods, i.e. recrystallization in water, and purification with isopropanol, cyclohexane, or isopropanol and cyclohexane. Purity of β-CD following the isopropanol method was over 99%, but the yield was only 40%. After cyclohexane treatment or the combined treatment with isopropanol and cyclohexane, purity was also over 99%, but yield was over 60%. Contaminants in commercial β-CD may be soluble or insoluble. Some contaminants would be bound in the inclusion cavity, and elimination of such contaminants by recrystallization in water was not successful. The purity and endothermic energy changes of β-CD were also determined by differential scanning calorimetry.

AB - Cyclodextrins are an important class of products made from starch, and have many applications in the food and other industries. Among the cyclodextrins, β-cyclodextrin (β-CD) is the most important and is produced in the largest amount. Some commercial preparations of β-CD contain contaminants which must be eliminated to enhance the purity of the product. The purity of β-CD was increased by four different methods, i.e. recrystallization in water, and purification with isopropanol, cyclohexane, or isopropanol and cyclohexane. Purity of β-CD following the isopropanol method was over 99%, but the yield was only 40%. After cyclohexane treatment or the combined treatment with isopropanol and cyclohexane, purity was also over 99%, but yield was over 60%. Contaminants in commercial β-CD may be soluble or insoluble. Some contaminants would be bound in the inclusion cavity, and elimination of such contaminants by recrystallization in water was not successful. The purity and endothermic energy changes of β-CD were also determined by differential scanning calorimetry.

UR - http://www.scopus.com/inward/record.url?scp=6244231680&partnerID=8YFLogxK

U2 - 10.1002/star.19960481008

DO - 10.1002/star.19960481008

M3 - 文章

AN - SCOPUS:6244231680

SN - 0038-9056

VL - 48

SP - 382

EP - 385

JO - Starch/Staerke

JF - Starch/Staerke

IS - 10

ER -

Efficiency of recrystallization methods for the purification of β-cyclodextrin

Abstract

Access to Document

Other files and links

Fingerprint

Cite this