Effects and mechanisms of tea and its bioactive compounds for the prevention and treatment of cardiovascular diseases: An updated review

Shi Yu Cao, Cai Ning Zhao, Ren You Gan, Xiao Yu Xu, Xin Lin Wei, Harold Corke, Atanas G. Atanasov, Hua Bin Li*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Cardiovascular diseases (CVDs) are critical global public health issues with high morbidity and mortality. Epidemiological studies have revealed that regular tea drinking is inversely associated with the risk of CVDs. Additionally, substantial in vitro and in vivo experimental studies have shown that tea and its bioactive compounds are effective in protecting against CVDs. The relevant mechanisms include reducing blood lipid, alleviating ischemia/reperfusion injury, inhibiting oxidative stress, enhancing endothelial function, attenuating inflammation, and protecting cardiomyocyte function. Moreover, some clinical trials also proved the protective role of tea against CVDs. In order to provide a better understanding of the relationship between tea and CVDs, this review summarizes the effects of tea and its bioactive compounds against CVDs and discusses potential mechanisms of action based on evidence from epidemiological, experimental, and clinical studies.

Original languageEnglish
Article number166
JournalAntioxidants
Volume8
Issue number6
DOIs
StatePublished - Jun 2019
Externally publishedYes

Keywords

  • Bioactive compounds
  • Cardiovascular diseases
  • EGCG
  • Mechanisms
  • Polyphenols
  • Tea

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