Edwardsiella tarda - Virulence mechanisms of an emerging gastroenteritis pathogen

Ka Yin Leung*, Bupe A. Siame, Byron J. Tenkink, Rebecca J. Noort, Yu Keung Mok

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

109 Scopus citations

Abstract

Human Edwardsiella tarda infections often manifest as gastroenteritis, but can become systemic and potentially lethal. E. tarda uses virulence factors that include type III and type VI secretion systems, quorum sensing, two-component systems, and exoenzymes to gain entry into and survive within the host. Better understanding of interactions between these factors will lead to the development of novel antimicrobials against E. tarda and other enterics.

Original languageEnglish
Pages (from-to)26-34
Number of pages9
JournalMicrobes and Infection
Volume14
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • Bacterial secretion systems
  • Edwardsiella tarda
  • Human gastroenteritis
  • T3SS and T6SS
  • Virulence mechanisms
  • Virulence regulation

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