Edwardsiella tarda - Virulence mechanisms of an emerging gastroenteritis pathogen

Ka Yin Leung; Bupe A. Siame; Byron J. Tenkink; Rebecca J. Noort; Yu Keung Mok

doi:10.1016/j.micinf.2011.08.005

Edwardsiella tarda - Virulence mechanisms of an emerging gastroenteritis pathogen

Ka Yin Leung^*, Bupe A. Siame, Byron J. Tenkink, Rebecca J. Noort, Yu Keung Mok

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

168 Scopus citations

Abstract

Human Edwardsiella tarda infections often manifest as gastroenteritis, but can become systemic and potentially lethal. E. tarda uses virulence factors that include type III and type VI secretion systems, quorum sensing, two-component systems, and exoenzymes to gain entry into and survive within the host. Better understanding of interactions between these factors will lead to the development of novel antimicrobials against E. tarda and other enterics.

Original language	English
Pages (from-to)	26-34
Number of pages	9
Journal	Microbes and Infection
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.micinf.2011.08.005
State	Published - Jan 2012
Externally published	Yes

Keywords

Bacterial secretion systems
Edwardsiella tarda
Human gastroenteritis
T3SS and T6SS
Virulence mechanisms
Virulence regulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2011.08.005

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title = "Edwardsiella tarda - Virulence mechanisms of an emerging gastroenteritis pathogen",

abstract = "Human Edwardsiella tarda infections often manifest as gastroenteritis, but can become systemic and potentially lethal. E. tarda uses virulence factors that include type III and type VI secretion systems, quorum sensing, two-component systems, and exoenzymes to gain entry into and survive within the host. Better understanding of interactions between these factors will lead to the development of novel antimicrobials against E. tarda and other enterics.",

keywords = "Bacterial secretion systems, Edwardsiella tarda, Human gastroenteritis, T3SS and T6SS, Virulence mechanisms, Virulence regulation",

author = "Leung, {Ka Yin} and Siame, {Bupe A.} and Tenkink, {Byron J.} and Noort, {Rebecca J.} and Mok, {Yu Keung}",

note = "Funding Information: Work in the authors{\textquoteright} laboratories was supported by a Natural Science and Engineering Research Council (NSERC) Discovery Grant ( 372373-2010 ) and a Trinity Western University Startup Grant ( 0488 ) to K.Y.L., a Biomedical Research Council (BMRC) grant from the Agency for Science Technology and Research (A*STAR), Singapore to Y.K.M. ( 07/1/21/19/495 ).",

year = "2012",

month = jan,

doi = "10.1016/j.micinf.2011.08.005",

language = "英语",

volume = "14",

pages = "26--34",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier USA",

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T1 - Edwardsiella tarda - Virulence mechanisms of an emerging gastroenteritis pathogen

AU - Leung, Ka Yin

AU - Siame, Bupe A.

AU - Tenkink, Byron J.

AU - Noort, Rebecca J.

AU - Mok, Yu Keung

N1 - Funding Information: Work in the authors’ laboratories was supported by a Natural Science and Engineering Research Council (NSERC) Discovery Grant ( 372373-2010 ) and a Trinity Western University Startup Grant ( 0488 ) to K.Y.L., a Biomedical Research Council (BMRC) grant from the Agency for Science Technology and Research (A*STAR), Singapore to Y.K.M. ( 07/1/21/19/495 ).

PY - 2012/1

Y1 - 2012/1

N2 - Human Edwardsiella tarda infections often manifest as gastroenteritis, but can become systemic and potentially lethal. E. tarda uses virulence factors that include type III and type VI secretion systems, quorum sensing, two-component systems, and exoenzymes to gain entry into and survive within the host. Better understanding of interactions between these factors will lead to the development of novel antimicrobials against E. tarda and other enterics.

AB - Human Edwardsiella tarda infections often manifest as gastroenteritis, but can become systemic and potentially lethal. E. tarda uses virulence factors that include type III and type VI secretion systems, quorum sensing, two-component systems, and exoenzymes to gain entry into and survive within the host. Better understanding of interactions between these factors will lead to the development of novel antimicrobials against E. tarda and other enterics.

KW - Bacterial secretion systems

KW - Edwardsiella tarda

KW - Human gastroenteritis

KW - T3SS and T6SS

KW - Virulence mechanisms

KW - Virulence regulation

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U2 - 10.1016/j.micinf.2011.08.005

DO - 10.1016/j.micinf.2011.08.005

M3 - 文献综述

C2 - 21924375

AN - SCOPUS:84355161684

SN - 1286-4579

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EP - 34

JO - Microbes and Infection

JF - Microbes and Infection

IS - 1

ER -

Edwardsiella tarda - Virulence mechanisms of an emerging gastroenteritis pathogen

Abstract

Keywords

UN SDGs

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