Differences in intramembrane particle distribution in young and old human erythrocytes

Julio F. Cordero, Pedro J. Rodríguez, Pedro J. Romero*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The distribution of intramembrane particles in human erythrocytes was studied by freeze-fracture on young and old cells and compared to that obtained after ATP depletion or following addition of a clustering agent. It was shown that intramembrane particles became aggregated and the mean particle density increased as the cells aged. Likewise, both particle aggregation and increased density were found in young cells after moderate ATP depletion. In contrast, mean particle density was markedly reduced in both cell types after exhaustive depletion. Paradoxically, Zn treatment led to decreased particle density in young cells, whilst producing the opposite effect in aged cells. The results suggest that their low ATP content may account for the increased particle density of senescent cells.

Original languageEnglish
Pages (from-to)423-431
Number of pages9
JournalCell Biology International
Issue number6
StatePublished - Jun 2004
Externally publishedYes


  • Ageing
  • Freeze-fracture
  • Human erythrocytes
  • IMP
  • Red cell sub-populations


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