Cellular responses evoked by different surface characteristics of intraosseous titanium implants

Liviu Feller; Yusuf Jadwat; Razia A.G. Khammissa; Robin Meyerov; Israel Schechter; Johan Lemmer

doi:10.1155/2015/171945

Cellular responses evoked by different surface characteristics of intraosseous titanium implants

Liviu Feller^*, Yusuf Jadwat, Razia A.G. Khammissa, Robin Meyerov, Israel Schechter, Johan Lemmer

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

132 Scopus citations

Abstract

The properties of biomaterials, including their surface microstructural topography and their surface chemistry or surface energy/wettability, affect cellular responses such as cell adhesion, proliferation, and migration. The nanotopography of moderately rough implant surfaces enhances the production of biological mediators in the peri-implant microenvironment with consequent recruitment of differentiating osteogenic cells to the implant surface and stimulates osteogenic maturation. Implant surfaces with moderately rough topography and with high surface energy promote osteogenesis, increase the ratio of bone-to-implant contact, and increase the bonding strength of the bone to the implant at the interface. Certain features of implant surface chemistry are also important in enhancing peri-implant bone wound healing. It is the purpose of this paper to review some of the more important features of titanium implant surfaces which have an impact on osseointegration.

Original language	English
Article number	171945
Journal	BioMed Research International
Volume	2015
DOIs	https://doi.org/10.1155/2015/171945
State	Published - 2015
Externally published	Yes

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title = "Cellular responses evoked by different surface characteristics of intraosseous titanium implants",

abstract = "The properties of biomaterials, including their surface microstructural topography and their surface chemistry or surface energy/wettability, affect cellular responses such as cell adhesion, proliferation, and migration. The nanotopography of moderately rough implant surfaces enhances the production of biological mediators in the peri-implant microenvironment with consequent recruitment of differentiating osteogenic cells to the implant surface and stimulates osteogenic maturation. Implant surfaces with moderately rough topography and with high surface energy promote osteogenesis, increase the ratio of bone-to-implant contact, and increase the bonding strength of the bone to the implant at the interface. Certain features of implant surface chemistry are also important in enhancing peri-implant bone wound healing. It is the purpose of this paper to review some of the more important features of titanium implant surfaces which have an impact on osseointegration.",

author = "Liviu Feller and Yusuf Jadwat and Khammissa, {Razia A.G.} and Robin Meyerov and Israel Schechter and Johan Lemmer",

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AU - Feller, Liviu

AU - Jadwat, Yusuf

AU - Khammissa, Razia A.G.

AU - Meyerov, Robin

AU - Schechter, Israel

AU - Lemmer, Johan

PY - 2015

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N2 - The properties of biomaterials, including their surface microstructural topography and their surface chemistry or surface energy/wettability, affect cellular responses such as cell adhesion, proliferation, and migration. The nanotopography of moderately rough implant surfaces enhances the production of biological mediators in the peri-implant microenvironment with consequent recruitment of differentiating osteogenic cells to the implant surface and stimulates osteogenic maturation. Implant surfaces with moderately rough topography and with high surface energy promote osteogenesis, increase the ratio of bone-to-implant contact, and increase the bonding strength of the bone to the implant at the interface. Certain features of implant surface chemistry are also important in enhancing peri-implant bone wound healing. It is the purpose of this paper to review some of the more important features of titanium implant surfaces which have an impact on osseointegration.

AB - The properties of biomaterials, including their surface microstructural topography and their surface chemistry or surface energy/wettability, affect cellular responses such as cell adhesion, proliferation, and migration. The nanotopography of moderately rough implant surfaces enhances the production of biological mediators in the peri-implant microenvironment with consequent recruitment of differentiating osteogenic cells to the implant surface and stimulates osteogenic maturation. Implant surfaces with moderately rough topography and with high surface energy promote osteogenesis, increase the ratio of bone-to-implant contact, and increase the bonding strength of the bone to the implant at the interface. Certain features of implant surface chemistry are also important in enhancing peri-implant bone wound healing. It is the purpose of this paper to review some of the more important features of titanium implant surfaces which have an impact on osseointegration.

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Cellular responses evoked by different surface characteristics of intraosseous titanium implants

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