Assay and functional analysis of dynamin-like Mx proteins

Georg Kochs*, Mike Reichelt, Dganit Danino, Jenny E. Hinshaw, Otto Haller

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Mx proteins are interferon-induced large guanosin triphosphatases (GTPases) that share structural and functional properties with dynamin and dynamin-like proteins, such as self-assembly and association with intracellular membranes. A unique property of some Mx proteins is their antiviral activity against a range of RNA viruses, including influenza viruses and members of the bunyavirus family. These viruses are inhibited at an early stage in their life cycle, soon after host cell entry and before genome amplification. The association of the human MxA GTPase with membranes of the endoplasmic reticulum seems to support its antiviral function by providing an interaction platform that facilitates viral target recognition, MxA oligomerization, and missorting of the resulting multiprotein complex into large intracellular aggregates.

Original languageEnglish
Article number55
Pages (from-to)632-643
Number of pages12
JournalMethods in Enzymology
Volume404
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint Dive into the research topics of 'Assay and functional analysis of dynamin-like Mx proteins'. Together they form a unique fingerprint.

Cite this