Versatile lifestyles of Edwardsiella: Free-living, pathogen, and core bacterium of the aquatic resistome

TY - JOUR

T1 - Versatile lifestyles of Edwardsiella: Free-living, pathogen, and core bacterium of the aquatic resistome

AU - Leung, Ka Yin

AU - Wang, Qiyao

AU - Zheng, Xiaochang

AU - Zhuang, Mei

AU - Yang, Zhiyun

AU - Shao, Shuai

AU - Achmon, Yigal

AU - Siame, Bupe A.

PY - 2021/12/30

Y1 - 2021/12/30

N2 - Edwardsiella species in aquatic environments exist either as individual planktonic cells or in communal biofilms. These organisms encounter multiple stresses, include changes in salinity, pH, temperature, and nutrients. Pathogenic species such as E. piscicida, can multiply within the fish hosts. Additionally, Edwardsiella species (E. tarda), can carry antibiotic resistance genes (ARGs) on chromosomes and/or plasmids, that can be transmitted to the microbiome via horizontal gene transfer. E. tarda serves as a core in the aquatic resistome. Edwardsiela uses molecular switches (RpoS and EsrB) to control gene expression for survival in different environments. We speculate that free-living Edwardsiella can transition to host-living and vice versa, using similar molecular switches. Understanding such transitions can help us understand how other similar aquatic bacteria switch from free-living to become pathogens. This knowledge can be used to devise ways to slow down the spread of ARGs and prevent disease outbreaks in aquaculture and clinical settings.

AB - Edwardsiella species in aquatic environments exist either as individual planktonic cells or in communal biofilms. These organisms encounter multiple stresses, include changes in salinity, pH, temperature, and nutrients. Pathogenic species such as E. piscicida, can multiply within the fish hosts. Additionally, Edwardsiella species (E. tarda), can carry antibiotic resistance genes (ARGs) on chromosomes and/or plasmids, that can be transmitted to the microbiome via horizontal gene transfer. E. tarda serves as a core in the aquatic resistome. Edwardsiela uses molecular switches (RpoS and EsrB) to control gene expression for survival in different environments. We speculate that free-living Edwardsiella can transition to host-living and vice versa, using similar molecular switches. Understanding such transitions can help us understand how other similar aquatic bacteria switch from free-living to become pathogens. This knowledge can be used to devise ways to slow down the spread of ARGs and prevent disease outbreaks in aquaculture and clinical settings.

KW - Edwardsiella

KW - pathogen

KW - free-living

KW - aquatic resistome

KW - virulence

KW - antibiotic resistance genes

KW - antibiotic resistant bacteria

U2 - 10.1080/21505594.2021.2006890

DO - 10.1080/21505594.2021.2006890

M3 - 文章

C2 - 34969351

SN - 2150-5594

JO - Virulence

JF - Virulence

ER -