Use of carbon supports with copper ion as a highly sensitive non-enzymatic glucose sensor

TY - JOUR

T1 - Use of carbon supports with copper ion as a highly sensitive non-enzymatic glucose sensor

AU - Zheng, Weiran

AU - Li, Yong

AU - Hu, Liangsheng

AU - Lee, Lawrence Yoon Suk

N1 - Publisher Copyright: © 2018 Elsevier B.V.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Nearly all current non-enzymatic electrochemical glucose sensors involve carefully designed metal/metal oxide nanomaterials and the complications of preparing electrocatalyst increase the fabrication cost and reduce the reproducibility of a sensor. Thus, a simple yet reliable and cost-effective glucose sensing system is much desired. Inspired by the glucose oxidation mechanism of copper-based nanomaterials, we developed a series of highly sensitive electrochemical glucose sensors using micromol level Cu2+ ions as an electrocatalyst. High sensitivities are achieved on various carbon-based electrodes (GCE: 614 mA M−1 cm−2; activated carbon: 1627 mA M−1 cm−2; carbon paper: 2149 mA M−1 cm−2; graphite powder: 1695 mA M−1 cm−2, and functionalized multi-walled carbon nanotube: 1842 mA M−1 cm−2). With short response time (<2 s), large linear range (0.02 μM–2.5 mM and 2.5–8.0 mM), high stability, and excellent tolerance to interference, Cu ion-based sensor was also validated for testing glucose level in real blood samples. Further studies show that carbon support (e.g., MWCNT-COOH) can be doped with nanomolar level Cu2+ to produce a practical solid electrode with an ultra-high sensitivity of 1732 mA M−1 cm−2, retaining the advantage of atomic efficiency. This work provides a new route to the rational design of simple, cheap, and highly effective electrochemical glucose sensors.

AB - Nearly all current non-enzymatic electrochemical glucose sensors involve carefully designed metal/metal oxide nanomaterials and the complications of preparing electrocatalyst increase the fabrication cost and reduce the reproducibility of a sensor. Thus, a simple yet reliable and cost-effective glucose sensing system is much desired. Inspired by the glucose oxidation mechanism of copper-based nanomaterials, we developed a series of highly sensitive electrochemical glucose sensors using micromol level Cu2+ ions as an electrocatalyst. High sensitivities are achieved on various carbon-based electrodes (GCE: 614 mA M−1 cm−2; activated carbon: 1627 mA M−1 cm−2; carbon paper: 2149 mA M−1 cm−2; graphite powder: 1695 mA M−1 cm−2, and functionalized multi-walled carbon nanotube: 1842 mA M−1 cm−2). With short response time (<2 s), large linear range (0.02 μM–2.5 mM and 2.5–8.0 mM), high stability, and excellent tolerance to interference, Cu ion-based sensor was also validated for testing glucose level in real blood samples. Further studies show that carbon support (e.g., MWCNT-COOH) can be doped with nanomolar level Cu2+ to produce a practical solid electrode with an ultra-high sensitivity of 1732 mA M−1 cm−2, retaining the advantage of atomic efficiency. This work provides a new route to the rational design of simple, cheap, and highly effective electrochemical glucose sensors.

KW - Activated carbon

KW - Carbon paper

KW - Copper ion

KW - Glucose

KW - Graphite

KW - MWCNT

KW - Sensor

UR - http://www.scopus.com/inward/record.url?scp=85056768181&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2018.10.164

DO - 10.1016/j.snb.2018.10.164

M3 - 文章

AN - SCOPUS:85056768181

SN - 0925-4005

VL - 282

SP - 187

EP - 196

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -