TY - JOUR
T1 - Role of proton balance in formation of self-assembled chitosan nanoparticles
AU - Dey, Anomitra
AU - Kamat, Aditya
AU - Nayak, Sonal
AU - Danino, Dganit
AU - Kesselman, Ellina
AU - Dandekar, Prajakta
AU - Jain, Ratnesh
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Researchers have explored the ability of chitosan to form nanoparticles, to suit varying applications, ranging from wound-healing to gene delivery. Ionic gelation is a widely used method for formulating chitosan nanoparticles, where self-assembly plays a crucial role. This self-assembly is initially promoted by hydrophilic-hydrophobic parity amongst individual chitosan residues, along with electrostatic and Van der Waals interactions with the cross-linker. However, until now the intrinsic ability of chitosan to self-assemble is not widely studied; hence, we investigate the self-assembly of chitosan, based on proton balance between its protonated and deprotonated residues, to promote facile nanoparticle synthesis. This is one of the first reports that highlights subtle but critical influence of proton balance in the chitosan polymer on the formation of chitosan nanoparticles.
AB - Researchers have explored the ability of chitosan to form nanoparticles, to suit varying applications, ranging from wound-healing to gene delivery. Ionic gelation is a widely used method for formulating chitosan nanoparticles, where self-assembly plays a crucial role. This self-assembly is initially promoted by hydrophilic-hydrophobic parity amongst individual chitosan residues, along with electrostatic and Van der Waals interactions with the cross-linker. However, until now the intrinsic ability of chitosan to self-assemble is not widely studied; hence, we investigate the self-assembly of chitosan, based on proton balance between its protonated and deprotonated residues, to promote facile nanoparticle synthesis. This is one of the first reports that highlights subtle but critical influence of proton balance in the chitosan polymer on the formation of chitosan nanoparticles.
KW - Chitosan nanoparticles
KW - Docking
KW - Protonation
KW - Self-assembly
KW - Umbrella sampling
UR - http://www.scopus.com/inward/record.url?scp=85043767240&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2018.03.017
DO - 10.1016/j.colsurfb.2018.03.017
M3 - 文章
C2 - 29558703
AN - SCOPUS:85043767240
SN - 0927-7765
VL - 166
SP - 127
EP - 134
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -