Pathway and protein engineering approaches to produce novel and commodity small molecules

Namita Bhan; Peng Xu; Mattheos A.G. Koffas

doi:10.1016/j.copbio.2013.02.019

Pathway and protein engineering approaches to produce novel and commodity small molecules

Namita Bhan, Peng Xu, Mattheos A.G. Koffas^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Nature has provided us the basis of designing the most integrated and efficacious production platforms. Cell factories via their millions of years of evolution have nearly perfected each of their production systems. We have been trying to imitate, utilize and tweak this system to our advantage by using slightly overlapping and greatly interdependent approaches such as metabolic engineering and systems biology to make nature work for us in an efficient and robust way, without producing toxic waste and/or unnecessary side products. Systems biology, metabolic engineering and 'omics' technologies have paved the way for protein and pathway engineering. To this end we will talk about the recent advances in production of novel pharmaceutical and commodity small molecules by designing novel proteins and pathways.

Original language	English
Pages (from-to)	1137-1143
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.copbio.2013.02.019
State	Published - Dec 2013
Externally published	Yes

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title = "Pathway and protein engineering approaches to produce novel and commodity small molecules",

abstract = "Nature has provided us the basis of designing the most integrated and efficacious production platforms. Cell factories via their millions of years of evolution have nearly perfected each of their production systems. We have been trying to imitate, utilize and tweak this system to our advantage by using slightly overlapping and greatly interdependent approaches such as metabolic engineering and systems biology to make nature work for us in an efficient and robust way, without producing toxic waste and/or unnecessary side products. Systems biology, metabolic engineering and 'omics' technologies have paved the way for protein and pathway engineering. To this end we will talk about the recent advances in production of novel pharmaceutical and commodity small molecules by designing novel proteins and pathways.",

author = "Namita Bhan and Peng Xu and Koffas, {Mattheos A.G.}",

note = "Funding Information: This work is supported by the startup funds and Biocatalysis Constellation funds awarded to M.A.G.K. by Rensselaer Polytechnic Institute. ",

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AU - Koffas, Mattheos A.G.

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N2 - Nature has provided us the basis of designing the most integrated and efficacious production platforms. Cell factories via their millions of years of evolution have nearly perfected each of their production systems. We have been trying to imitate, utilize and tweak this system to our advantage by using slightly overlapping and greatly interdependent approaches such as metabolic engineering and systems biology to make nature work for us in an efficient and robust way, without producing toxic waste and/or unnecessary side products. Systems biology, metabolic engineering and 'omics' technologies have paved the way for protein and pathway engineering. To this end we will talk about the recent advances in production of novel pharmaceutical and commodity small molecules by designing novel proteins and pathways.

AB - Nature has provided us the basis of designing the most integrated and efficacious production platforms. Cell factories via their millions of years of evolution have nearly perfected each of their production systems. We have been trying to imitate, utilize and tweak this system to our advantage by using slightly overlapping and greatly interdependent approaches such as metabolic engineering and systems biology to make nature work for us in an efficient and robust way, without producing toxic waste and/or unnecessary side products. Systems biology, metabolic engineering and 'omics' technologies have paved the way for protein and pathway engineering. To this end we will talk about the recent advances in production of novel pharmaceutical and commodity small molecules by designing novel proteins and pathways.

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Pathway and protein engineering approaches to produce novel and commodity small molecules

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