Iridium(III)-Catalyzed CH Amidation of Arylphosphoryls Leading to a P-Stereogenic Center

Donghyeon Gwon; Donggun Lee; Jiyu Kim; Sehoon Park; Sukbok Chang

doi:10.1002/chem.201404151

Iridium(III)-Catalyzed CH Amidation of Arylphosphoryls Leading to a P-Stereogenic Center

Donghyeon Gwon, Donggun Lee, Jiyu Kim, Sehoon Park^*, Sukbok Chang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Direct CH amidation of arylphosphoryl compounds has been developed by using an Ir^IIIcatalyst system under mild conditions. A wide range of substrates could be employed with high functional-group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P-chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de).

Original language	English
Pages (from-to)	12421-12425
Number of pages	5
Journal	Chemistry - A European Journal
Volume	20
Issue number	39
DOIs	https://doi.org/10.1002/chem.201404151
State	Published - 22 Sep 2014
Externally published	Yes

Keywords

CH functionalization
asymmetric induction
chirality
iridium catalysis
phosphine oxides

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10.1002/chem.201404151

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title = "Iridium(III)-Catalyzed CH Amidation of Arylphosphoryls Leading to a P-Stereogenic Center",

abstract = "Direct CH amidation of arylphosphoryl compounds has been developed by using an IrIIIcatalyst system under mild conditions. A wide range of substrates could be employed with high functional-group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P-chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de).",

keywords = "CH functionalization, asymmetric induction, chirality, iridium catalysis, phosphine oxides",

author = "Donghyeon Gwon and Donggun Lee and Jiyu Kim and Sehoon Park and Sukbok Chang",

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AU - Gwon, Donghyeon

AU - Lee, Donggun

AU - Kim, Jiyu

AU - Park, Sehoon

AU - Chang, Sukbok

PY - 2014/9/22

Y1 - 2014/9/22

N2 - Direct CH amidation of arylphosphoryl compounds has been developed by using an IrIIIcatalyst system under mild conditions. A wide range of substrates could be employed with high functional-group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P-chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de).

AB - Direct CH amidation of arylphosphoryl compounds has been developed by using an IrIIIcatalyst system under mild conditions. A wide range of substrates could be employed with high functional-group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P-chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de).

KW - CH functionalization

KW - asymmetric induction

KW - chirality

KW - iridium catalysis

KW - phosphine oxides

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ER -

Iridium(III)-Catalyzed CH Amidation of Arylphosphoryls Leading to a P-Stereogenic Center

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Keywords

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