Internalization of silica nanoparticles into fluid liposomes: Formation of interesting hybrid colloids

Raphael Michel; Ellina Kesselman; Tobias Plostica; Dganit Danino; Michael Gradzielski

doi:10.1002/anie.201406927

Internalization of silica nanoparticles into fluid liposomes: Formation of interesting hybrid colloids

Raphael Michel, Ellina Kesselman, Tobias Plostica, Dganit Danino, Michael Gradzielski

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The formation of hybrid materials consisting of membrane-coated silica nanoparticles (SiNPs) concentrated within small unilamellar vesicles (SUVs) of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) is described. They are formed by a simple self-assembly process resulting from invagination of the SiNPs into the SUVs and subsequent vesicle fusion, thereby retaining an almost constant size. This process was followed under conditions where it proceeds slowly and could be analyzed in structural detail. The finally formed well-defined SiNP-filled vesicles are long-time stable hybrid colloids and their structure is conveniently controlled by the initial mixing ratio of SiNPs and vesicles.

Original language	English
Pages (from-to)	12441-12445
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	53
Issue number	46
DOIs	https://doi.org/10.1002/anie.201406927
State	Published - 10 Nov 2014
Externally published	Yes

Keywords

Endocytosis
Hybrid colloids
Internalization
Liposomes
Nanoparticles

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title = "Internalization of silica nanoparticles into fluid liposomes: Formation of interesting hybrid colloids",

abstract = "The formation of hybrid materials consisting of membrane-coated silica nanoparticles (SiNPs) concentrated within small unilamellar vesicles (SUVs) of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) is described. They are formed by a simple self-assembly process resulting from invagination of the SiNPs into the SUVs and subsequent vesicle fusion, thereby retaining an almost constant size. This process was followed under conditions where it proceeds slowly and could be analyzed in structural detail. The finally formed well-defined SiNP-filled vesicles are long-time stable hybrid colloids and their structure is conveniently controlled by the initial mixing ratio of SiNPs and vesicles.",

keywords = "Endocytosis, Hybrid colloids, Internalization, Liposomes, Nanoparticles",

author = "Raphael Michel and Ellina Kesselman and Tobias Plostica and Dganit Danino and Michael Gradzielski",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley-VCH Verlag GmbH &Co. KGaA,Weinheim.",

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T1 - Internalization of silica nanoparticles into fluid liposomes

T2 - Formation of interesting hybrid colloids

AU - Michel, Raphael

AU - Kesselman, Ellina

AU - Plostica, Tobias

AU - Danino, Dganit

AU - Gradzielski, Michael

PY - 2014/11/10

Y1 - 2014/11/10

N2 - The formation of hybrid materials consisting of membrane-coated silica nanoparticles (SiNPs) concentrated within small unilamellar vesicles (SUVs) of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) is described. They are formed by a simple self-assembly process resulting from invagination of the SiNPs into the SUVs and subsequent vesicle fusion, thereby retaining an almost constant size. This process was followed under conditions where it proceeds slowly and could be analyzed in structural detail. The finally formed well-defined SiNP-filled vesicles are long-time stable hybrid colloids and their structure is conveniently controlled by the initial mixing ratio of SiNPs and vesicles.

AB - The formation of hybrid materials consisting of membrane-coated silica nanoparticles (SiNPs) concentrated within small unilamellar vesicles (SUVs) of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) is described. They are formed by a simple self-assembly process resulting from invagination of the SiNPs into the SUVs and subsequent vesicle fusion, thereby retaining an almost constant size. This process was followed under conditions where it proceeds slowly and could be analyzed in structural detail. The finally formed well-defined SiNP-filled vesicles are long-time stable hybrid colloids and their structure is conveniently controlled by the initial mixing ratio of SiNPs and vesicles.

KW - Endocytosis

KW - Hybrid colloids

KW - Internalization

KW - Liposomes

KW - Nanoparticles

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M3 - 文章

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AN - SCOPUS:84915745860

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JO - Angewandte Chemie - International Edition

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Internalization of silica nanoparticles into fluid liposomes: Formation of interesting hybrid colloids

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Keywords

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