TY - JOUR
T1 - Homochiral MOF–Polymer Mixed Matrix Membranes for Efficient Separation of Chiral Molecules
AU - Lu, Yizhihao
AU - Zhang, Huacheng
AU - Chan, Jun Yong
AU - Ou, Ranwen
AU - Zhu, Haijin
AU - Forsyth, Maria
AU - Marijanovic, Emilia M.
AU - Doherty, Cara M.
AU - Marriott, Philip J.
AU - Holl, Mark M.Banaszak
AU - Wang, Huanting
N1 - Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/11/18
Y1 - 2019/11/18
N2 - Homochiral metal–organic framework (MOF) membranes have been recently reported for chiral separations. However, only a few high-quality homochiral polycrystalline MOF membranes have been fabricated due to the difficulty in crystallization of a chiral MOF layer without defects on porous substrates. Alternatively, mixed matrix membranes (MMMs), which combine potential advantages of MOFs and polymers, have been widely demonstrated for gas separation and water purification. Here we report novel homochiral MOF–polymer MMMs for efficient chiral separation. Homochirality was successfully incorporated into achiral MIL-53-NH2 nanocrystals by post-synthetic modification with amino acids, such as l-histidine (l-His) and l-glutamic acid (l-Glu). The MIL-53-NH-l-His and MIL-53-NH-l-Glu nanocrystals were then embedded into polyethersulfone (PES) matrix to form homochiral MMMs, which exhibited excellent enantioselectivity for racemic 1-phenylethanol with the highest enantiomeric excess value up to 100 %. This work, as an example, demonstrates the feasibility of fabricating diverse large-scale homochiral MOF-based MMMs for chiral separation.
AB - Homochiral metal–organic framework (MOF) membranes have been recently reported for chiral separations. However, only a few high-quality homochiral polycrystalline MOF membranes have been fabricated due to the difficulty in crystallization of a chiral MOF layer without defects on porous substrates. Alternatively, mixed matrix membranes (MMMs), which combine potential advantages of MOFs and polymers, have been widely demonstrated for gas separation and water purification. Here we report novel homochiral MOF–polymer MMMs for efficient chiral separation. Homochirality was successfully incorporated into achiral MIL-53-NH2 nanocrystals by post-synthetic modification with amino acids, such as l-histidine (l-His) and l-glutamic acid (l-Glu). The MIL-53-NH-l-His and MIL-53-NH-l-Glu nanocrystals were then embedded into polyethersulfone (PES) matrix to form homochiral MMMs, which exhibited excellent enantioselectivity for racemic 1-phenylethanol with the highest enantiomeric excess value up to 100 %. This work, as an example, demonstrates the feasibility of fabricating diverse large-scale homochiral MOF-based MMMs for chiral separation.
KW - chiral resolution
KW - chirality
KW - homochiral membrane separation
KW - metal–organic frameworks
KW - mixed-matrix membrane
UR - http://www.scopus.com/inward/record.url?scp=85074404134&partnerID=8YFLogxK
U2 - 10.1002/anie.201910408
DO - 10.1002/anie.201910408
M3 - 文章
C2 - 31535784
AN - SCOPUS:85074404134
SN - 1433-7851
VL - 58
SP - 16928
EP - 16935
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 47
ER -