Drug-loaded nanoparticles and supramolecular nanotubes formed from a volatile microemulsion with bile salt derivatives

Katrin Margulis-Goshen; Maria Chiara Di Gregorio; Nicolae Viorel Pavel; Ludmila Abezgauz; Dganit Danino; Josè Vázquez Tato; Victor Hugo Soto Tellini; Shlomo Magdassi; Luciano Galantini

doi:10.1039/c3cp50258a

Drug-loaded nanoparticles and supramolecular nanotubes formed from a volatile microemulsion with bile salt derivatives

Katrin Margulis-Goshen, Maria Chiara Di Gregorio, Nicolae Viorel Pavel, Ludmila Abezgauz, Dganit Danino, Josè Vázquez Tato, Victor Hugo Soto Tellini, Shlomo Magdassi^*, Luciano Galantini

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The main objective of this study was to form nanoparticles of a model hydrophobic drug, celecoxib, from a volatile microemulsion stabilized by a bile salt derivative. Nanoparticles were obtained by conversion of the microemulsion nanodroplets with the dissolved drug into solid nanometric particles. The use of bile salt derivatives as the surfactants for the formation of a microemulsion enabled significantly higher loading of the drug in both the microemulsion and nanoparticles, compared with the native bile salt. In addition, superior stability of the particles was achieved with the bile salt derivatives, and drug crystallization was inhibited. Interestingly, differences in particle stability and crystallization inhibition were observed between two bile salt derivatives differing only by one hydroxyl group on the bile salt backbone, indicating the delicate balance of interactions in the system. For one of the derivatives, upon dispersion of the nanoparticles in water, they spontaneously arranged into well-defined elongated nanometric tubules as detected and attested by cryo-TEM. It was found that the drug present in nanoparticles induces formation of the nanotubes. This journal is

Original language	English
Pages (from-to)	6016-6024
Number of pages	9
Journal	Physical Chemistry Chemical Physics
Volume	15
Issue number	16
DOIs	https://doi.org/10.1039/c3cp50258a
State	Published - 28 Apr 2013
Externally published	Yes

Access to Document

10.1039/c3cp50258a

Cite this

@article{a4c86baa0cd1481abf7cf9a5fffa8dba,

title = "Drug-loaded nanoparticles and supramolecular nanotubes formed from a volatile microemulsion with bile salt derivatives",

abstract = "The main objective of this study was to form nanoparticles of a model hydrophobic drug, celecoxib, from a volatile microemulsion stabilized by a bile salt derivative. Nanoparticles were obtained by conversion of the microemulsion nanodroplets with the dissolved drug into solid nanometric particles. The use of bile salt derivatives as the surfactants for the formation of a microemulsion enabled significantly higher loading of the drug in both the microemulsion and nanoparticles, compared with the native bile salt. In addition, superior stability of the particles was achieved with the bile salt derivatives, and drug crystallization was inhibited. Interestingly, differences in particle stability and crystallization inhibition were observed between two bile salt derivatives differing only by one hydroxyl group on the bile salt backbone, indicating the delicate balance of interactions in the system. For one of the derivatives, upon dispersion of the nanoparticles in water, they spontaneously arranged into well-defined elongated nanometric tubules as detected and attested by cryo-TEM. It was found that the drug present in nanoparticles induces formation of the nanotubes. This journal is",

author = "Katrin Margulis-Goshen and {Di Gregorio}, {Maria Chiara} and Pavel, {Nicolae Viorel} and Ludmila Abezgauz and Dganit Danino and {V{\'a}zquez Tato}, Jos{\`e} and {Soto Tellini}, {Victor Hugo} and Shlomo Magdassi and Luciano Galantini",

year = "2013",

month = apr,

day = "28",

doi = "10.1039/c3cp50258a",

language = "英语",

volume = "15",

pages = "6016--6024",

journal = "Physical Chemistry Chemical Physics",

issn = "1463-9076",

publisher = "Royal Society of Chemistry",

number = "16",

}

TY - JOUR

T1 - Drug-loaded nanoparticles and supramolecular nanotubes formed from a volatile microemulsion with bile salt derivatives

AU - Margulis-Goshen, Katrin

AU - Di Gregorio, Maria Chiara

AU - Pavel, Nicolae Viorel

AU - Abezgauz, Ludmila

AU - Danino, Dganit

AU - Vázquez Tato, Josè

AU - Soto Tellini, Victor Hugo

AU - Magdassi, Shlomo

AU - Galantini, Luciano

PY - 2013/4/28

Y1 - 2013/4/28

N2 - The main objective of this study was to form nanoparticles of a model hydrophobic drug, celecoxib, from a volatile microemulsion stabilized by a bile salt derivative. Nanoparticles were obtained by conversion of the microemulsion nanodroplets with the dissolved drug into solid nanometric particles. The use of bile salt derivatives as the surfactants for the formation of a microemulsion enabled significantly higher loading of the drug in both the microemulsion and nanoparticles, compared with the native bile salt. In addition, superior stability of the particles was achieved with the bile salt derivatives, and drug crystallization was inhibited. Interestingly, differences in particle stability and crystallization inhibition were observed between two bile salt derivatives differing only by one hydroxyl group on the bile salt backbone, indicating the delicate balance of interactions in the system. For one of the derivatives, upon dispersion of the nanoparticles in water, they spontaneously arranged into well-defined elongated nanometric tubules as detected and attested by cryo-TEM. It was found that the drug present in nanoparticles induces formation of the nanotubes. This journal is

AB - The main objective of this study was to form nanoparticles of a model hydrophobic drug, celecoxib, from a volatile microemulsion stabilized by a bile salt derivative. Nanoparticles were obtained by conversion of the microemulsion nanodroplets with the dissolved drug into solid nanometric particles. The use of bile salt derivatives as the surfactants for the formation of a microemulsion enabled significantly higher loading of the drug in both the microemulsion and nanoparticles, compared with the native bile salt. In addition, superior stability of the particles was achieved with the bile salt derivatives, and drug crystallization was inhibited. Interestingly, differences in particle stability and crystallization inhibition were observed between two bile salt derivatives differing only by one hydroxyl group on the bile salt backbone, indicating the delicate balance of interactions in the system. For one of the derivatives, upon dispersion of the nanoparticles in water, they spontaneously arranged into well-defined elongated nanometric tubules as detected and attested by cryo-TEM. It was found that the drug present in nanoparticles induces formation of the nanotubes. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84876560528&partnerID=8YFLogxK

U2 - 10.1039/c3cp50258a

DO - 10.1039/c3cp50258a

M3 - 文章

C2 - 23493872

AN - SCOPUS:84876560528

SN - 1463-9076

VL - 15

SP - 6016

EP - 6024

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

IS - 16

ER -

Drug-loaded nanoparticles and supramolecular nanotubes formed from a volatile microemulsion with bile salt derivatives

Abstract

Access to Document

Other files and links

Fingerprint

Cite this