Detection of mcr-1 Gene among Escherichia coli Isolates from Farmed Fish and Characterization of mcr-1-Bearing IncP Plasmids

Luchao Lv; Yuping Cao; Peixin Yu; Raorao Huang; Jing Wang; Qiaoling Wen; Chanping Zhi; Qianhui Zhang; Jian Hua Liu

doi:10.1128/AAC.02378-17

Detection of mcr-1 Gene among Escherichia coli Isolates from Farmed Fish and Characterization of mcr-1-Bearing IncP Plasmids

Luchao Lv, Yuping Cao, Peixin Yu, Raorao Huang, Jing Wang, Qiaoling Wen, Chanping Zhi, Qianhui Zhang, Jian Hua Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The presence of the mcr-1 gene in Escherichia coli isolated from retail freshwater fish was investigated. Seven (3.65%) clonally unrelated original E. coli isolates from grass carp were positive for mcr-1. The mcr-1 genes were encoded by either chromosomes (n 2) or conjugative plasmids (2 IncI2, 2 IncP, and 1 IncX4). The IncP plasmids were similar to other mcr-1-harboring IncP plasmids from China, though the insertion sites varied. Our report warrants further surveillance of resistance genes in aquaculture.

Original language	English
Article number	e02378-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	3
DOIs	https://doi.org/10.1128/AAC.02378-17
State	Published - Mar 2018
Externally published	Yes

Keywords

Colistin resistance
Enterobacteriaceae
Escherichia coli
Fish
IncP
Mcr-1
Plasmid mediated

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02378-17

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title = "Detection of mcr-1 Gene among Escherichia coli Isolates from Farmed Fish and Characterization of mcr-1-Bearing IncP Plasmids",

abstract = "The presence of the mcr-1 gene in Escherichia coli isolated from retail freshwater fish was investigated. Seven (3.65%) clonally unrelated original E. coli isolates from grass carp were positive for mcr-1. The mcr-1 genes were encoded by either chromosomes (n 2) or conjugative plasmids (2 IncI2, 2 IncP, and 1 IncX4). The IncP plasmids were similar to other mcr-1-harboring IncP plasmids from China, though the insertion sites varied. Our report warrants further surveillance of resistance genes in aquaculture.",

keywords = "Colistin resistance, Enterobacteriaceae, Escherichia coli, Fish, IncP, Mcr-1, Plasmid mediated",

author = "Luchao Lv and Yuping Cao and Peixin Yu and Raorao Huang and Jing Wang and Qiaoling Wen and Chanping Zhi and Qianhui Zhang and Liu, {Jian Hua}",

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doi = "10.1128/AAC.02378-17",

language = "英语",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

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T1 - Detection of mcr-1 Gene among Escherichia coli Isolates from Farmed Fish and Characterization of mcr-1-Bearing IncP Plasmids

AU - Lv, Luchao

AU - Cao, Yuping

AU - Yu, Peixin

AU - Huang, Raorao

AU - Wang, Jing

AU - Wen, Qiaoling

AU - Zhi, Chanping

AU - Zhang, Qianhui

AU - Liu, Jian Hua

PY - 2018/3

Y1 - 2018/3

N2 - The presence of the mcr-1 gene in Escherichia coli isolated from retail freshwater fish was investigated. Seven (3.65%) clonally unrelated original E. coli isolates from grass carp were positive for mcr-1. The mcr-1 genes were encoded by either chromosomes (n 2) or conjugative plasmids (2 IncI2, 2 IncP, and 1 IncX4). The IncP plasmids were similar to other mcr-1-harboring IncP plasmids from China, though the insertion sites varied. Our report warrants further surveillance of resistance genes in aquaculture.

AB - The presence of the mcr-1 gene in Escherichia coli isolated from retail freshwater fish was investigated. Seven (3.65%) clonally unrelated original E. coli isolates from grass carp were positive for mcr-1. The mcr-1 genes were encoded by either chromosomes (n 2) or conjugative plasmids (2 IncI2, 2 IncP, and 1 IncX4). The IncP plasmids were similar to other mcr-1-harboring IncP plasmids from China, though the insertion sites varied. Our report warrants further surveillance of resistance genes in aquaculture.

KW - Colistin resistance

KW - Enterobacteriaceae

KW - Escherichia coli

KW - Fish

KW - IncP

KW - Mcr-1

KW - Plasmid mediated

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U2 - 10.1128/AAC.02378-17

DO - 10.1128/AAC.02378-17

M3 - 文章

C2 - 29311062

AN - SCOPUS:85042361665

SN - 0066-4804

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

M1 - e02378-17

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Detection of mcr-1 Gene among Escherichia coli Isolates from Farmed Fish and Characterization of mcr-1-Bearing IncP Plasmids

Abstract

Keywords

UN SDGs

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