Biological Events in Periodontal Ligament and Alveolar Bone Associated with Application of Orthodontic Forces

L. Feller; R. A.G. Khammissa; I. Schechter; G. Thomadakis; J. Fourie; J. Lemmer

doi:10.1155/2015/876509

Biological Events in Periodontal Ligament and Alveolar Bone Associated with Application of Orthodontic Forces

L. Feller^*, R. A.G. Khammissa, I. Schechter, G. Thomadakis, J. Fourie, J. Lemmer

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Orthodontic force-induced stresses cause dynamic alterations within the extracellular matrix and within the cytoskeleton of cells in the periodontal ligament and alveolar bone, mediating bone remodelling, ultimately enabling orthodontic tooth movement. In the periodontal ligament and alveolar bone, the mechanically induced tensile strains upregulate the expression of osteogenic genes resulting in bone formation, while mechanically induced compressive strains mediate predominantly catabolic tissue changes and bone resorption. In this review article we summarize some of the currently known biological events occurring in the periodontal ligament and in the alveolar bone in response to application of orthodontic forces and how these facilitate tooth movement.

Original language	English
Article number	876509
Journal	The Scientific World Journal
Volume	2015
DOIs	https://doi.org/10.1155/2015/876509
State	Published - 2015
Externally published	Yes

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abstract = "Orthodontic force-induced stresses cause dynamic alterations within the extracellular matrix and within the cytoskeleton of cells in the periodontal ligament and alveolar bone, mediating bone remodelling, ultimately enabling orthodontic tooth movement. In the periodontal ligament and alveolar bone, the mechanically induced tensile strains upregulate the expression of osteogenic genes resulting in bone formation, while mechanically induced compressive strains mediate predominantly catabolic tissue changes and bone resorption. In this review article we summarize some of the currently known biological events occurring in the periodontal ligament and in the alveolar bone in response to application of orthodontic forces and how these facilitate tooth movement.",

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AB - Orthodontic force-induced stresses cause dynamic alterations within the extracellular matrix and within the cytoskeleton of cells in the periodontal ligament and alveolar bone, mediating bone remodelling, ultimately enabling orthodontic tooth movement. In the periodontal ligament and alveolar bone, the mechanically induced tensile strains upregulate the expression of osteogenic genes resulting in bone formation, while mechanically induced compressive strains mediate predominantly catabolic tissue changes and bone resorption. In this review article we summarize some of the currently known biological events occurring in the periodontal ligament and in the alveolar bone in response to application of orthodontic forces and how these facilitate tooth movement.

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JO - The Scientific World Journal

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Biological Events in Periodontal Ligament and Alveolar Bone Associated with Application of Orthodontic Forces

Abstract

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