Alternative methods of attenuating Salmonella species for potential vaccine use

D. R. Wilson; S. Chatfield; J. Betts; A. Griffiths; K. Y. Leung; G. Dougan; B. B. Finlay

doi:10.1016/0923-2508(90)90117-9

Alternative methods of attenuating Salmonella species for potential vaccine use

D. R. Wilson^*, S. Chatfield, J. Betts, A. Griffiths, K. Y. Leung, G. Dougan, B. B. Finlay

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Because of their invasive properties, Salmonella species are uniquely suited for use as live oral vaccines, and mutants attenuated in general metabolic functions show promise as vaccine strains. We have identified a Salmonella choleraesuis transposon mutant which is deficient in abilities to attach to, invade or penetrate through animal cells. This mutant is avirulent in mice, yet is able to persist within the liver, spleen and gut-associated lymphoid tissue for periods which may be adequate for induction of secretory, humoral and cell-mediated immunity. This and other strains attenuated in factors specifically required for Salmonella pathogenesis may have potential as vaccine strains.

Original language	English
Pages (from-to)	827-830
Number of pages	4
Journal	Research in Microbiology
Volume	141
Issue number	7-8
DOIs	https://doi.org/10.1016/0923-2508(90)90117-9
State	Published - 1990
Externally published	Yes

Keywords

Mutant, Attenuating species
Salmonella choleraesuis, Transposon, Vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0923-2508(90)90117-9

Cite this

@article{6f9ea5d0507a4e098b0dd54ad74e595f,

title = "Alternative methods of attenuating Salmonella species for potential vaccine use",

abstract = "Because of their invasive properties, Salmonella species are uniquely suited for use as live oral vaccines, and mutants attenuated in general metabolic functions show promise as vaccine strains. We have identified a Salmonella choleraesuis transposon mutant which is deficient in abilities to attach to, invade or penetrate through animal cells. This mutant is avirulent in mice, yet is able to persist within the liver, spleen and gut-associated lymphoid tissue for periods which may be adequate for induction of secretory, humoral and cell-mediated immunity. This and other strains attenuated in factors specifically required for Salmonella pathogenesis may have potential as vaccine strains.",

keywords = "Mutant, Attenuating species, Salmonella choleraesuis, Transposon, Vaccine",

author = "Wilson, {D. R.} and S. Chatfield and J. Betts and A. Griffiths and Leung, {K. Y.} and G. Dougan and Finlay, {B. B.}",

note = "Funding Information: This work was supported by operatingg rants to B.B.F. from the British ColumbiaH ealth Care Research Foundation, the Medical Research Council and the Bacterial Diseases Centre of Excellence. B.B.F. was a recipient of a post-doctorate fellowship from the Alberta Heritage Foundation for Medical Research. D.R.W. is a recipient of a Natural Sciences and EngineeringR esearch Council of Canada 1967 Science and EngineeringS cholarship.",

year = "1990",

doi = "10.1016/0923-2508(90)90117-9",

language = "英语",

volume = "141",

pages = "827--830",

journal = "Research in Microbiology",

issn = "0923-2508",

publisher = "Elsevier Masson SAS",

number = "7-8",

}

TY - JOUR

T1 - Alternative methods of attenuating Salmonella species for potential vaccine use

AU - Wilson, D. R.

AU - Chatfield, S.

AU - Betts, J.

AU - Griffiths, A.

AU - Leung, K. Y.

AU - Dougan, G.

AU - Finlay, B. B.

N1 - Funding Information: This work was supported by operatingg rants to B.B.F. from the British ColumbiaH ealth Care Research Foundation, the Medical Research Council and the Bacterial Diseases Centre of Excellence. B.B.F. was a recipient of a post-doctorate fellowship from the Alberta Heritage Foundation for Medical Research. D.R.W. is a recipient of a Natural Sciences and EngineeringR esearch Council of Canada 1967 Science and EngineeringS cholarship.

PY - 1990

Y1 - 1990

N2 - Because of their invasive properties, Salmonella species are uniquely suited for use as live oral vaccines, and mutants attenuated in general metabolic functions show promise as vaccine strains. We have identified a Salmonella choleraesuis transposon mutant which is deficient in abilities to attach to, invade or penetrate through animal cells. This mutant is avirulent in mice, yet is able to persist within the liver, spleen and gut-associated lymphoid tissue for periods which may be adequate for induction of secretory, humoral and cell-mediated immunity. This and other strains attenuated in factors specifically required for Salmonella pathogenesis may have potential as vaccine strains.

AB - Because of their invasive properties, Salmonella species are uniquely suited for use as live oral vaccines, and mutants attenuated in general metabolic functions show promise as vaccine strains. We have identified a Salmonella choleraesuis transposon mutant which is deficient in abilities to attach to, invade or penetrate through animal cells. This mutant is avirulent in mice, yet is able to persist within the liver, spleen and gut-associated lymphoid tissue for periods which may be adequate for induction of secretory, humoral and cell-mediated immunity. This and other strains attenuated in factors specifically required for Salmonella pathogenesis may have potential as vaccine strains.

KW - Mutant, Attenuating species

KW - Salmonella choleraesuis, Transposon, Vaccine

UR - http://www.scopus.com/inward/record.url?scp=0025674029&partnerID=8YFLogxK

U2 - 10.1016/0923-2508(90)90117-9

DO - 10.1016/0923-2508(90)90117-9

M3 - 文章

C2 - 1966254

AN - SCOPUS:0025674029

SN - 0923-2508

VL - 141

SP - 827

EP - 830

JO - Research in Microbiology

JF - Research in Microbiology

IS - 7-8

ER -

Alternative methods of attenuating Salmonella species for potential vaccine use

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this