Abstract
A short and practical synthesis of oseltamivir was accomplished in 11 steps from inexpensive and abundant diethyl d-tartrate starting material. This azide-free route featured an asymmetric aza-Henry reaction and a domino nitro-Michael/Horner-Wadsworth-Emmons (HWE) reaction as the key steps to construct the relevant cyclohexene ring of the product, which provided an economical and practical alternative for the synthesis of oseltamivir.
Original language | English |
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Pages (from-to) | 3125-3128 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 75 |
Issue number | 9 |
DOIs | |
State | Published - 7 May 2010 |
Externally published | Yes |